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1

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

Karran, Eric, Mercken, Marc, Strooper, Bart De

Journal:

Nature Reviews Drug Discovery

Year:

2011

Language:

english

File:

PDF, 931 KB

english, 2011

2

Vitamin K2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency

Vos, M., Esposito, G., Edirisinghe, J. N., Vilain, S., Haddad, D. M., Slabbaert, J. R., Van Meensel, S., Schaap, O., De Strooper, B., Meganathan, R., Morais, V. A., Verstreken, P.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.59 MB

english, 2012

3

Alzheimer's disease

Scheltens, Philip, Blennow, Kaj, Breteler, Monique M B, de Strooper, Bart, Frisoni, Giovanni B, Salloway, Stephen, Van der Flier, Wiesje Maria

Journal:

Year:

2016

Language:

english

File:

PDF, 321 KB

english, 2016

4

A method for verifying concurrent Java components based on an analysis of concurrency failures

Brad Long, Paul Strooper, Luke Wildman

Journal:

Concurrency and Computation: Practice and Experience

Year:

2007

Language:

english

File:

PDF, 204 KB

english, 2007

5

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

Benilova, Iryna, Karran, Eric, De Strooper, Bart

Journal:

Nature Neuroscience

Year:

2012

Language:

english

File:

PDF, 544 KB

english, 2012

6

Drosophila transgenic RNAi screen of genes implicated in human neurological disease

Dominik M. Haddad⁎, Melissa Vos, Vanessa A. Morais, Maarten Leyssen, Joke Allemeersch, Bart De Strooper, Patrik Verstreken

Journal:

Year:

2011

Language:

english

File:

PDF, 64 KB

english, 2011

7

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

Arranz, Amaia M, De Strooper, Bart

Journal:

The Lancet Neurology

Year:

2019

Language:

english

File:

PDF, 473 KB

english, 2019

8

Deficiency of Aph1B/C- -secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment

Dejaegere, T., Serneels, L., Schafer, M. K., Van Biervliet, J., Horre, K., Depboylu, C., Alvarez-Fischer, D., Herreman, A., Willem, M., Haass, C., Hoglinger, G. U., D'Hooge, R., De Strooper, B.

Journal:

Proceedings of the National Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 167 KB

english, 2008

9

Cholesterol Depletion Inhibits the Generation of β -amyloid in Hippocampal Neurons

Mikael Simons, Patrick Keller, Bart De Strooper, Konrad Beyreuther, Carlos G. Dotti and Kai Simons

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.24 MB

english, 1998

10

ClassBench: a Framework for Automated Class Testing

DANIEL HOFFMAN, PAUL STROOPER

Journal:

Software: Practice and Experience

Year:

1997

Language:

english

File:

PDF, 183 KB

english, 1997

11

MicroRNA regulation of Alzheimer's Amyloid precursor protein expression

Sébastien S. Hébert, Katrien Horré, Laura Nicolaï, Bruno Bergmans, Aikaterini S. Papadopoulou, André Delacourte, Bart De Strooper

Journal:

Neurobiology of Disease

Year:

2009

Language:

english

File:

PDF, 756 KB

english, 2009

12

Tudca, a bile acid, attenuates amyloid beta deposition and rescues memory deficits in app/ps1 mice

Nunes, Ana, Fonseca, Maria, Viana, Ricardo, Lo, Adrian, De Strooper, Bart, D'Hooge, Rudi, Rodrigues, Cecília

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 73 KB

english, 2011

13

Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration

Acx, Hermien, Serneels, Lutgarde, Radaelli, Enrico, Muyldermans, Serge, Vincke, Cécile, Pepermans, Elise, Müller, Ulrike, Chávez‐Gutiérrez, Lucía, De Strooper, Bart

Journal:

EMBO Molecular Medicine

Year:

2017

Language:

english

File:

PDF, 5.90 MB

english, 2017

14

Differential contribution of the three Aph1 genes to -secretase activity in vivo

Serneels, L., Dejaegere, T., Craessaerts, K., Horre, K., Jorissen, E., Tousseyn, T., Hebert, S., Coolen, M., Martens, G., Zwijsen, A., Annaert, W., Hartmann, D., De Strooper, B.

Journal:

Proceedings of the National Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 685 KB

english, 2005

15

10.1038/19083

De Strooper, Bart, Kopan, Raphael, Annaert, Wim, Cupers, Philippe, Saftig, Paul, Craessaerts, Katleen, Mumm, Jeffrey S., Schroeter, Eric H., Schrijvers, Vincent, Wolfe, Michael S., Ray, William J., Go

Journal:

Year:

1999

Language:

english

File:

PDF, 543 KB

english, 1999

16

Diabetes and Alzheimer’s Disease: A Link not as Simple as it Seems

Salas, Isabel H., De Strooper, Bart

Journal:

Neurochemical Research

Year:

2018

Language:

english

File:

PDF, 836 KB

english, 2018

17

Boundary values and automated component testing

Daniel Hoffman, Paul Strooper, Lee White

Journal:

Software Testing, Verification and Reliability

Year:

1999

Language:

english

File:

PDF, 191 KB

english, 1999

18

COMPARISONS OF THE UNSATURATED HYDRAULIC CONDUCTIVITY OF A COARSE-TEXTURED SOIL AS DETERMINED IN THE FIELD, IN THE LABORATORY, AND WITH MATHEMATICAL MODELS

MICHIELS, P., HARTMANN, R., STROOPER, E. DE

Journal:

Year:

1989

File:

PDF, 376 KB

1989

19

Grammar-based test generation with YouGen

Daniel Malcolm Hoffman, David Ly-Gagnon, Paul Strooper, Hong-Yi Wang

Journal:

Software: Practice and Experience

Year:

2011

Language:

english

File:

PDF, 735 KB

english, 2011

20

The World of Dementia Beyond 2020

Henry Brodaty, Monique M. B. Breteler, Steven T. DeKosky, Pascale Dorenlot, Laura Fratiglioni, Christoph Hock, Paul-Ariel Kenigsberg, Philip Scheltens, Bart De Strooper

Journal:

Journal of the American Geriatrics Society

Year:

2011

Language:

english

File:

PDF, 76 KB

english, 2011

21

A model-based development approach for the verification of real-time Java code

Niusha Hakimi Pour, Paul Strooper, Andy Wellings

Journal:

Concurrency and Computation: Practice and Experience

Year:

2011

Language:

english

File:

PDF, 1.17 MB

english, 2011

22

Active -Secretase Complexes Contain Only One of Each Component

Sato, T., Diehl, T. S., Narayanan, S., Funamoto, S., Ihara, Y., De Strooper, B., Steiner, H., Haass, C., Wolfe, M. S.

Journal:

Journal of Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 581 KB

english, 2007

23

Comparing the performance of FAM19A4 methylation analysis, cytology and HPV16/18 genotyping for the detection of cervical (pre)cancer in high-risk HPV-positive women of a gynecologic outpatient population (COMETH study)

Luttmer, Roosmarijn, De Strooper, Lise M.A., Berkhof, Johannes, Snijders, Peter J.F., Dijkstra, Maaike G., Uijterwaal, Margot H., Steenbergen, Renske D.M., van Kemenade, Folkert J., Rozendaal, Lawrenc

Journal:

International Journal of Cancer

Year:

2016

Language:

english

File:

PDF, 456 KB

english, 2016

24

Gene Dosage Effect on γ-Secretase Component Aph-1b in a Rat Model for Neurodevelopmental Disorders

Marcel W. Coolen, Karen M.J. Van Loo, Nick N.H.M. Van Bakel, David J. Pulford, Lutgarde Serneels, Bart De Strooper, Bart A. Ellenbroek, Alexander R. Cools, Gerard J.M. Martens

Journal:

Year:

2005

Language:

english

File:

PDF, 325 KB

english, 2005

25

Lessons from a Failed γ-Secretase Alzheimer Trial

De Strooper, Bart

Journal:

Year:

2014

Language:

english

File:

PDF, 666 KB

english, 2014

26

Non-coding RNAs with essential roles in neurodegenerative disorders

Evgenia Salta, Bart De Strooper

Journal:

The Lancet Neurology

Year:

2012

Language:

english

File:

PDF, 605 KB

english, 2012

27

Learning by Failing: Ideas and Concepts to Tackle γ-Secretases in Alzheimer's Disease and Beyond

De Strooper, Bart, Chávez Gutiérrez, Lucía

Journal:

Annual Review of Pharmacology

Year:

2015

Language:

english

File:

PDF, 793 KB

english, 2015

28

Validation of the FAM19A4/mir124-2 DNA methylation test for both lavage- and brush-based self-samples to detect cervical (pre)cancer in HPV-positive women

De Strooper, Lise M.A., Verhoef, Viola M.J., Berkhof, Johannes, Hesselink, Albertus T., de Bruin, Helena M.E., van Kemenade, Folkert J., Bosgraaf, Remko P., Bekkers, Ruud L.M., Massuger, Leon F.A.G.,

Journal:

Gynecologic Oncology

Year:

2016

Language:

english

File:

PDF, 748 KB

english, 2016

29

A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases

Mandemakers, W., Morais, V. A., De Strooper, B.

Journal:

Journal of Cell Science

Year:

2007

Language:

english

File:

PDF, 635 KB

english, 2007

30

Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

Bart De Strooper

Journal:

Year:

2003

Language:

english

File:

PDF, 65 KB

english, 2003

31

[IEEE 2015 24th Australasian Software Engineering Conference (ASWEC) - Adelaide, SA, Australia (2015.9.28-2015.10.1)] 2015 24th Australasian Software Engineering Conference - Automation of Test Case Generation from Behavior Tree Requirements Models

Lindsay, Peter A., Kromodimoeljo, Sentot, Strooper, Paul A., Almorsy, Mohamed

Year:

2015

Language:

english

File:

PDF, 1.04 MB

english, 2015

32

Subsurface water flow on a slope in the loamy region of Belgium

P. Michiels, R. Hartmann, E. De Strooper

Journal:

Earth Surface Processes and Landforms

Year:

1989

Language:

english

File:

PDF, 576 KB

english, 1989

33

Two case studies in grammar-based test generation

Daniel Hoffman, Hong-Yi Wang, Mitch Chang, David Ly-Gagnon, Lewis Sobotkiewicz, Paul Strooper

Journal:

Journal of Systems and Software

Year:

2010

Language:

english

File:

PDF, 1.18 MB

english, 2010

34

An industry/university collaboration to upgrade software engineering knowledge and skills in industry

David Carrington, Paul Strooper, Sharron Newby, Terry Stevenson

Journal:

Journal of Systems and Software

Year:

2005

Language:

english

File:

PDF, 298 KB

english, 2005

35

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression

Hebert, S. S., Horre, K., Nicolai, L., Papadopoulou, A. S., Mandemakers, W., Silahtaroglu, A. N., Kauppinen, S., Delacourte, A., De Strooper, B.

Journal:

Proceedings of the National Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 946 KB

english, 2008

36

Notch Is a Critical Component of the Mouse Somitogenesis Oscillator and Is Essential for the Formation of the Somites

Ferjentsik, Zoltan, Hayashi, Shinichi, Dale, J. Kim, Bessho, Yasumasa, Herreman, An, De Strooper, Bart, del Monte, Gonzalo, de la Pompa, Jose Luis, Maroto, Miguel, Henry, Clarissa A.

Journal:

Year:

2009

Language:

english

File:

PDF, 4.80 MB

english, 2009

37

Amyloid Precursor Protein Accumulation in Lewy Body Dementia and Alzheimers Disease

Van Gool, D., De Strooper, B., Van Leuven, F., Dom, R.

Journal:

Dementia and Geriatric Cognitive Disorders

Year:

1995

File:

PDF, 2.42 MB

1995

38

Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

Huiping Tu, Omar Nelson, Arseny Bezprozvanny, Zhengnan Wang, Sheu-Fen Lee, Yi-Heng Hao, Lutgarde Serneels, Bart De Strooper, Gang Yu, Ilya Bezprozvanny

Journal:

Year:

2006

Language:

english

File:

PDF, 957 KB

english, 2006

39

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model

Rice, Heather C., Marcassa, Gabriele, Chrysidou, Iordana, Horré, Katrien, Young-Pearse, Tracy L., Müller, Ulrike C., Saito, Takashi, Saido, Takaomi C., Vassar, Robert, de Wit, Joris, De Strooper, Bart

Journal:

Molecular Neurodegeneration

Year:

2020

Language:

english

File:

PDF, 2.38 MB

english, 2020

40

Methylation Analysis of the FAM19A4 Gene in Cervical Scrapes Is Highly Efficient in Detecting Cervical Carcinomas and Advanced CIN2/3 Lesions

De Strooper, L. M. A., Meijer, C. J. L. M., Berkhof, J., Hesselink, A. T., Snijders, P. J. F., Steenbergen, R. D. M., Heideman, D. A. M.

Journal:

Cancer Prevention Research

Year:

2014

Language:

english

File:

PDF, 957 KB

english, 2014

41

API documentation with executable examples

Daniel Hoffman, Paul Strooper

Journal:

Journal of Systems and Software

Year:

2003

Language:

english

File:

PDF, 436 KB

english, 2003

42

Neurons Generated from APP/APLP1/APLP2 Triple Knockout Embryonic Stem Cells Behave Normally in Vitro and in Vivo: Lack of Evidence for a Cell Autonomous Role of the Amyloid Precursor Protein in Neuronal Differentiation

Bruno A. Bergmans, S. Ali M. Shariati, Ron L.P. Habets, Patrik Verstreken, Luc Schoonjans, Ulrike Müller, Carlos G. Dotti, Bart De Strooper

Journal:

Year:

2010

Language:

english

File:

PDF, 849 KB

english, 2010

43

GPR3 modulation of the Gamma-secretase complex and Abeta generation in Alzheimer's disease

Amantha Thathiah, Bart De Strooper, Katrien Horre

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 51 KB

english, 2011

44

Development of a multiplex methylation-specific PCR as candidate triage test for women with an HPV-positive cervical scrape

Suzanne Snellenberg, Lise MA De Strooper, Albertus T Hesselink, Chris JLM Meijer, Peter JF Snijders, Daniëlle AM Heideman, Renske DM Steenbergen

Journal:

Year:

2012

Language:

english

File:

PDF, 829 KB

english, 2012

45

miR-29a maintains hematopoietic stem cell self-renewal and is required for leukemic transformation

Park, Christopher, Hu, Wenhuo, Dooley, James, Chung, Stephen, Shin, Yu Sup, De Strooper, Bart, Liston, Adrian

Journal:

Experimental Hematology

Year:

2013

Language:

english

File:

PDF, 41 KB

english, 2013

46

[IEEE 2012 19th Asia-Pacific Software Engineering Conference (APSEC) - Hong Kong, China (2012.12.4-2012.12.7)] 2012 19th Asia-Pacific Software Engineering Conference - Exploring an Approach to Model-Based Testing from Behavior Trees

Hakimipour, Niusha, Strooper, Paul

Year:

2012

Language:

english

File:

PDF, 4.63 MB

english, 2012

47

An overlooked neurotoxic species in Alzheimer's disease

Benilova, Iryna, De Strooper, Bart

Journal:

Nature Neuroscience

Year:

2011

Language:

english

File:

PDF, 186 KB

english, 2011

48

Parkin Interacts with Ambra1 to Induce Mitophagy

Van Humbeeck, C., Cornelissen, T., Hofkens, H., Mandemakers, W., Gevaert, K., De Strooper, B., Vandenberghe, W.

Journal:

Journal of Neuroscience

Year:

2011

Language:

english

File:

PDF, 3.58 MB

english, 2011

49

Presenilins and -Secretase: Structure, Function, and Role in Alzheimer Disease

De Strooper, B., Iwatsubo, T., Wolfe, M. S.

Journal:

Cold Spring Harbor Perspectives in Medicine

Year:

2012

Language:

english

File:

PDF, 1.10 MB

english, 2012

50

The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Protease in Vivo

Zhou, L., Barao, S., Laga, M., Bockstael, K., Borgers, M., Gijsen, H., Annaert, W., Moechars, D., Mercken, M., Gevaer, K., De Strooper, B.

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 3.00 MB

english, 2012

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